China Pharma Univ. SHP2 compound 23

China Pharma Univ. SHP2 compound 23: sourced facts only. name: "Notably, lead compound 23 with potent SHP2 inhibitory activity (IC50 = 17.7 nM) effectively inhibited the proliferation, migration, and invasion of MIA PaCa-2 pancreatic cancer cells." [PMID:37754066]; target: "Notably, lead compound 23 with potent SHP2 inhibitory activity (IC50 = 17.7 nM) effectively inhibited the proliferation, migration, and invasion of MIA PaCa-2 pancreatic cancer cells." [PMID:37754066]; developer: "Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China." [PMID:37754066]; stage: "Furthermore, compound 23 featured great in vivo pharmacokinetic properties (AUCpo = 4320 nM·h; F = 66.3%) and exhibited significant antitumor efficacy in the MIA PaCa-2 xenograft mouse model." [PMID:37754066]