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Chinese Academy of Sciences H1N1 split-virion vaccine
- Development stage
- Unknown
- Lead developer
- Chinese Academy of Sciences
- Modality
- Whole Inactivated Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
The Chinese Academy of Sciences H1N1 split-virion vaccine is an inactivated influenza vaccine candidate developed to prevent infection by the H1N1 subtype of Influenza A virus, specifically targeting the 2009 swine-origin strain (S-OIV). The vaccine is produced by inactivating the virus and subsequently using detergents to disrupt (split) the virion, a process designed to reduce reactogenicity while maintaining immunogenicity. It is administered via intramuscular injection and aims to elicit a robust immune response, including the production of hemagglutination-inhibiting (HAI) antibodies against the viral hemagglutinin protein and the activation of T-cell mediated cellular immunity, as measured by interferon-gamma ELISPOT and tetramer staining.
- Other names
- split-virion inactivated A (H1N1) vaccineS-OIV vaccineH1N1 split-vaccineH-1N1 split-vaccineH 1N1 split-vaccine
02
Targets
HA (Hemagglutinin)
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