Chinese Academy of Sciences STING compound 5c

Chinese Academy of Sciences STING compound 5c: sourced facts only. name: "Extensive structure-activity relationship (SAR) study allowed us to identify compound 5c with cellular human- and mouse-STING inhibitory IC50 values of 44 and 32 nM, respectively." [PMID:40614559]; target: "Extensive structure-activity relationship (SAR) study allowed us to identify compound 5c with cellular human- and mouse-STING inhibitory IC50 values of 44 and 32 nM, respectively." [PMID:40614559]; developer: "Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, PR China; Lingang Laboratory, Shanghai, 200031, PR China; ShanghaiTech University, School of Physical Science & Technology, Shanghai, 201210, PR China." [PMID:40614559]; stage: "Compound 5c also demonstrated robust in vivo anti-inflammatory efficacy on STING agonist-stimulated systemic inflammation and cisplatin-induced acute kidney injury (AKI) mice models." [PMID:40614559]