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Chinese medicine WT
- Development stage
- Unknown
- Lead developer
- Changhua Christian Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Chinese medicine WT is an investigational traditional Chinese medicine (TCM) formulation developed by Changhua Christian Hospital for the treatment of spinocerebellar ataxia type 3 (SCA3). Administered as an oral concentrated powder, the formulation contains bioactive constituents that exhibit neuroprotective properties against glutamate-induced excitotoxicity, a primary driver of neurodegeneration in SCA3. Its mechanism of action involves the up-regulation of insulin-like growth factor-1 (IGF-1) protein expression and the promotion of neurogenesis. The drug is currently undergoing Phase 2 clinical evaluation (NCT05038306) to determine its safety and efficacy in slowing disease progression and improving motor function in patients with SCA3.
- Other names
- Chinese Medicine WT
02
Targets
Glu (Glutamate)IGF-1 (Insulin-like growth factor 1)
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