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chitosan + mineral trioxide aggregate
- Development stage
- Phase 2
- Lead developer
- Nourhan M. Aly
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
This combination therapy consists of a 3D porous chitosan scaffold and Mineral Trioxide Aggregate (MTA), specifically the fast-setting EndoCem Zr formulation. It is designed for use as a pulpotomy agent in mature permanent teeth affected by irreversible pulpitis. Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, serves as a scaffold to support cellular attachment and tissue regeneration within the pulp chamber. MTA is a bioactive bioceramic material that releases calcium ions and creates an alkaline environment, promoting the formation of a mineralized dentinal bridge and providing a bacterial-tight seal. The combination aims to maintain tooth vitality and promote pulp healing as an alternative to conventional root canal treatment.
- Brand names
- EndoCem Zr
- Other names
- Chitosan scaffold/ MTA pulp dressing materialChitosan + MTAChitosan scaffold and Mineral trioxide aggregate
02
Targets
BMP2 (Bone morphogenetic protein 2)TGFB1 (Transforming growth factor Beta-1 proprotein)
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