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chitosan-encapsulated gloriosa superba tuber nanoparticles
- Development stage
- Preclinical
- Lead developer
- Bharathiar University
- Modality
- Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
01
Overview
Chitosan-encapsulated Gloriosa superba tuber nanoparticles (CEGSTNs) are an experimental nano-formulation consisting of an extract from the tuber of the medicinal plant *Gloriosa superba* encapsulated within a chitosan polymer matrix. Developed primarily for the treatment of cervical cancer, CEGSTNs exert their anticancer effects by downregulating the expression of the Spindle and kinetochore-associated complex subunit 3 (SKA3). This downregulation leads to the inactivation of the PI3K/AKT/mTOR signaling pathway, which subsequently inhibits cell proliferation and induces apoptosis in cancer cells. Preclinical studies in HeLa cell lines and Wistar rat models have demonstrated significant efficacy and a favorable safety profile, with no observed acute toxicity or adverse effects on hematological or biochemical parameters.
- Other names
- Chitosan Encapsulated G. superba Tuber Nanoparticles
02
Targets
mTOR (Mammalian target of rapamycin kinase)AKT (RAC-alpha serine/threonine-protein kinase)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)
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