chloral hydrate

Chloral hydrate is a sedative-hypnotic drug historically used for the short-term treatment of insomnia, as well as to relieve anxiety and induce sleep before surgery. It has also been used after surgery for pain management and to treat alcohol withdrawal symptoms[1][5][8]. Chloral hydrate acts by depressing the central nervous system, producing sedation and hypnosis. Its primary mechanism involves its rapid metabolism in the liver to trichloroethanol, which is responsible for most of its pharmacological effects[6]. The drug has a narrow safety margin and can be habit-forming; abrupt discontinuation after prolonged use may result in severe withdrawal symptoms[3][5]. Due to safety concerns and the availability of safer alternatives, chloral hydrate is no longer widely available or recommended in many countries including the United States[1].

Brand names

SomnoteNortec

Other names

trichloroacetaldehyde monohydrateNoctec