Drug intelligence / Profile preview

chloramphenicol + betamethasone + homatropine

Development stage
Unknown
Lead developer
Shahid Beheshti University of Medical Sciences
Modality
Small Molecules
Administration
Ophthalmic
01

Overview

This combination therapy represents the standard conventional therapy protocol utilized at Shahid Beheshti University of Medical Sciences for the management of corneal epithelial defects following diabetic vitrectomy. The regimen consists of three primary components: chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis; betamethasone, a potent corticosteroid used to mitigate ocular inflammation; and homatropine, an antimuscarinic agent that serves as a cycloplegic to prevent synechiae and alleviate pain associated with ciliary spasm. In clinical trial contexts, this combination is typically administered as topical eye drops to promote corneal healing and prevent postoperative complications such as infection and excessive inflammation.

Other names
conventional therapy (Shahid Beheshti University of Medical Sciences)conventional therapy-Shahid Beheshti University of Medical Sciences-corneal epithelial defect
02

Targets

PTC (50S ribosomal peptidyl transferase center)mAChR (Muscarinic acetylcholine receptors)GR (Glucocorticoid receptor)

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