chloramphenicol + prednisolone

Threolone is a topical ointment combining chloramphenicol (3.0%), a broad-spectrum antibiotic, and prednisolone (0.5%), an anti-inflammatory corticosteroid. This combination medication is designed for treating various skin infections and inflammatory conditions. ## Composition and Formulation Threolone is formulated as a yellowish ointment for topical application. Besides its active ingredients, it contains several excipients including petrolatum yellow (yellow soft paraffin), lanolin anhydrous (wool fat), mineral oil (liquid paraffin), and colloidal silicon dioxide[4]. ## Therapeutic Uses Threolone is indicated for various skin conditions including: - Infected eczema - Pruritic lesions - Angular stomatitis - Impetigo - External otitis - Pyoderma - Other skin infections caused by organisms sensitive to chloramphenicol[3][4] The medication works through a dual mechanism: chloramphenicol eliminates infections caused by sensitive organisms, while prednisolone reduces inflammation, resulting in decreased erythema, desquamation, and pruritus[4]. ## Dosage and Administration The recommended dosage is to apply a thin layer of the ointment 2-4 times daily to the infected area. Important administration notes include: - The ointment should not be applied near the eyes - Patients should consult their physician if no improvement occurs after 4-5 days of treatment[3][4] ## Contraindications Threolone is contraindicated in: - Patients with hypersensitivity to any ingredient in the preparation - Skin tuberculosis, herpes simplex, vaccinia, and varicella - External auditory canal of patients with perforated eardrum - Patients with personal or family history of blood dyscrasias including aplastic anemia - Ophthalmic use[3] ## Side Effects Potential side effects include: - Local reactions: burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin maceration, secondary infection, skin atrophy, striae, and miliaria[3] - Serious adverse effects requiring immediate discontinuation: bone marrow suppression, aplastic anemia, angioneurotic edema, anaphylactic shock, hives, fever, skin inflammation, wheezing, facial swelling, and reduced blood count[1] ## Special Precautions Special care should be taken during pregnancy and lactation. The medication contains lanolin anhydrous, which may cause skin irritation such as contact dermatitis[2]. If sensitization occurs, use should be discontinued, and patients should be monitored for potential overgrowth of non-susceptible organisms, including fungi[3]. Threolone is available in tubes of 10g and 20g and is dispensed only with a doctor's prescription[1][3][4].

Brand names

Threolone

Other names

chloramphenicol + prednisolone ointment