chlorazolamide

Chlorazolamide (5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide) is a potent sulfonamide-based inhibitor of carbonic anhydrase (CA) isozymes, specifically CA I, II, and IV. These enzymes play a critical role in the secretion of aqueous humor in the eye. Although the parent sulfonamide exhibits poor topical efficacy in lowering intraocular pressure (IOP) when administered as a suspension, its metal complexes—including derivatives of magnesium, zinc, manganese, and copper—have shown significant IOP-lowering effects in animal models. The drug's mechanism involves the near-total inhibition of CA II in ocular tissues, which reduces fluid production and makes it a candidate for the treatment of glaucoma and ocular hypertension.

Other names

5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide