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Drug intelligence / Profile preview
Chlordiazepoxide
- Development stage
- Approved
- Lead developer
- Roche
- Modality
- Small Molecules
- Administration
- Oral, Intramuscular, Intravenous
01
Overview
Chlordiazepoxide is a benzodiazepine used primarily for the management of anxiety disorders and for the short-term relief of symptoms of anxiety. It is also indicated for the treatment of withdrawal symptoms associated with acute alcoholism and preoperative apprehension and anxiety. Chlordiazepoxide acts as a central nervous system depressant by enhancing the effect of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the brain, thereby decreasing abnormal electrical activity. The drug possesses anxiolytic, sedative, hypnotic, anticonvulsant, and amnesic properties. In addition to its use as a single agent, chlordiazepoxide is available in combination products with clidinium (for gastrointestinal disorders) and amitriptyline (for depression). It was developed by Hoffmann-La Roche in the late 1950s[3][4][5][6].
- Brand names
- LibriumPoxiLibritabsMitran
- Other names
- chlordiazepoxide hydrochloride
02
Targets
BZD site (GABA-A receptor benzodiazepine site)GABAA (Gamma-aminobutyric acid receptor)
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