Drug intelligence / Profile preview

Chlordiazepoxide

Development stage
Approved
Lead developer
Roche
Modality
Small Molecules
Administration
Oral, Intramuscular, Intravenous
01

Overview

Chlordiazepoxide is a benzodiazepine used primarily for the management of anxiety disorders and for the short-term relief of symptoms of anxiety. It is also indicated for the treatment of withdrawal symptoms associated with acute alcoholism and preoperative apprehension and anxiety. Chlordiazepoxide acts as a central nervous system depressant by enhancing the effect of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the brain, thereby decreasing abnormal electrical activity. The drug possesses anxiolytic, sedative, hypnotic, anticonvulsant, and amnesic properties. In addition to its use as a single agent, chlordiazepoxide is available in combination products with clidinium (for gastrointestinal disorders) and amitriptyline (for depression). It was developed by Hoffmann-La Roche in the late 1950s[3][4][5][6].

Brand names
LibriumPoxiLibritabsMitran
Other names
chlordiazepoxide hydrochloride
02

Targets

BZD site (GABA-A receptor benzodiazepine site)

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