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chlorhexidine + cetylpyridinium chloride + hydrogen peroxide
- Development stage
- Unknown
- Lead developer
- Dental School
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
chlorhexidine + cetylpyridinium chloride + hydrogen peroxide is a combination antimicrobial mouthwash formulation being investigated for the reduction of dental plaque and the treatment of gingivitis. Chlorhexidine (CHX) is a bisbiguanide antiseptic that binds to bacterial cell walls and disrupts the cell membrane, leading to cytoplasmic leakage. Cetylpyridinium chloride (CPC) is a quaternary ammonium compound that similarly disrupts bacterial membranes and inhibits cell metabolism. Hydrogen peroxide (H2O2) serves as an oxidizing agent that produces free radicals to damage bacterial components and also acts as a whitening agent to mitigate tooth staining often associated with chlorhexidine use. This specific triple combination has been evaluated in Phase 3 clinical trials by the Dental School of the National and Kapodistrian University of Athens.
- Other names
- CHX + CPC + H2O2 mouthwashchlorhexidine/cetylpyridinium chloride/hydrogen peroxide mouthwash
02
Targets
TA (Teichoic acid)
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