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chlorhexidine + Citrus aurantium amara extract + hyaluronic acid
- Development stage
- Unknown
- Lead developer
- Sapienza University of Rome
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
This combination oral rinse formulation consists of 0.09% chlorhexidine digluconate, Citrox (a proprietary bioflavonoid complex derived from *Citrus aurantium amara*), and hyaluronic acid. Developed for post-surgical oral care in patients with periodontitis, the formulation leverages the broad-spectrum antiseptic properties of chlorhexidine alongside the synergistic antimicrobial and antioxidant effects of citrus bioflavonoids. The inclusion of hyaluronic acid is intended to promote tissue regeneration and accelerate wound healing in the post-surgical phase. This specific combination, often marketed under the Curaprox Perio Plus+ line, aims to maintain high clinical efficacy in plaque control and gingival health while minimizing common chlorhexidine side effects such as tooth staining and taste alteration.
- Brand names
- Perio Plus+ RegenerateCitrox
- Other names
- CHX 0.09% + Citrox + HACHX 0.09% + Citrox + Hyaluronic Acid
02
Targets
PE (Phosphatidylethanolamine)CD44 (CD44 antigen)
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