Drug intelligence / Profile preview

chlorin e6

Development stage
Preclinical
Lead developer
Apo Care Pharma
Modality
Light/Condition-Responsive Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Intravenous, Topical, Intravesical
01

Overview

Chlorin e6 is a second-generation photosensitizer derived from porphyrins and is used primarily in photodynamic therapy (PDT) for cancer treatment. Upon activation by light (typically around 660 nm), it generates reactive oxygen species (ROS) that induce cell cycle arrest, autophagy, or apoptosis in targeted cells. This mechanism makes it effective against various tumor types including melanoma and other cancers. Chlorin e6 has high ROS generation capacity and deep tissue penetration due to its absorption properties. It is also being explored as a sonosensitizer in sonodynamic therapy and for combination therapies such as chemo-photodynamic therapy[1][4][7].

Brand names
FotolonPhotolon
Other names
chlorin e6PhytochlorinChlorine e6CHLORIN E6 TRISODIUM SALT
02

Targets

ALB (Human serum albumin)

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