chlorogenic acid

Chlorogenic acid is a natural polyphenol compound, specifically the ester of caffeic acid and quinic acid, found abundantly in coffee beans and various plants. It is known for its antioxidant, anti-inflammatory, and potential chemopreventive properties. Chlorogenic acid has been investigated for its effects on cardiovascular health, blood glucose regulation (anti-diabetic effect), weight management (anti-obesity effect), and as a possible adjunct in cancer therapy. Mechanistically, it acts by inhibiting inflammatory pathways such as NF-κB signaling and modulating TLR4/MyD88 axis activity, leading to reduced production of pro-inflammatory mediators like TNF-α, NO, COX-2, and PGE2[3][6][8]. It has not been approved as a prescription drug or food additive but is widely used as a dietary supplement[5].

Other names

5-O-caffeoylquinic acid3-O-caffeoylquinic acidgreen coffee extractcoffee bean extract