chloroprocaine

Chloroprocaine is an ester-type local anesthetic primarily used for the production of local or regional anesthesia, including infiltration, peripheral nerve block, epidural, caudal, and subarachnoid (spinal) anesthesia in adults. It acts by binding to the alpha subunit on the cytoplasmic region of voltage-gated sodium channels in neuronal cell membranes, inhibiting sodium influx and thereby blocking nerve impulse conduction. This results in a reversible loss of sensation with a rapid onset (6–12 minutes) and short duration of action (up to 60 minutes). Chloroprocaine is especially favored for procedures requiring quick onset and short duration of anesthesia. At therapeutic doses it has minimal cardiovascular effects but can cause central nervous system stimulation or depression at toxic concentrations[2][3][4][5][8].

Brand names

NesacaineNesacaine-MPFClorotekal

Other names

chloroprocaine hydrochloride