chloroprocaine hydrochloride 2% injection

Chloroprocaine hydrochloride 2% injection (brand name: Nesacaine) is a short-acting, amino-ester class local anesthetic. It exerts its anesthetic effect by binding to and blocking voltage-gated sodium channels in peripheral neurons, thereby preventing the influx of sodium ions required for the initiation and conduction of nerve impulses. Characterized by a rapid onset of action (6–12 minutes) and a short duration of action (up to 60 minutes), chloroprocaine is rapidly metabolized by plasma esterases, which minimizes the risk of systemic accumulation and toxicity. While FDA-approved for infiltration, nerve block, epidural, and caudal anesthesia, it is also being evaluated in Phase 3 clinical trials by Johns Hopkins University as an investigational intraperitoneal lavage agent to reduce postoperative pain and nausea in women undergoing elective cesarean delivery.

Brand names

NesacaineNesacaine-MPF

Other names

Chloroprocaine Hcl 2% Injchloroprocainechloroprocaine HClchloroprocaine HCl 2%chloroprocaine hydrochloridechloroprocaine hydrochloride 2%