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chloroquine + gold sodium thiomalate

Development stage: Preclinical
Modality: Small Molecules
Administration: Intramuscular, Oral

Overview

A combination of chloroquine (CQ) and gold sodium thiomalate (GST), both of which are disease-modifying antirheumatic drugs (DMARDs) used in the treatment of rheumatoid arthritis and other inflammatory conditions. These drugs work through different mechanisms to suppress inflammation. Chloroquine reduces IL-1β mRNA expression and inhibits phosphorylation of mitogen-activated protein kinase (MAPK) p38, while gold sodium thiomalate inhibits IL-1β secretion by interfering with posttranslational IL-1β processing through selective inhibition of interleukin-1 converting enzyme (ICE)/caspase-1. The combination has been studied for its potential synergistic effects in reducing cytokine production and inflammation in rheumatoid arthritis.

Other names: CQ + GST

Targets

MAPK14 (p38 mitogen-activated protein kinase alpha)CASP1 (Caspase-1)

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