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Drug intelligence / Profile preview
chlorpheniramine + dextromethorphan (Indi Pharma)
- Development stage
- Unknown
- Lead developer
- Indi Pharma
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Expectus D is an oral combination cough syrup developed and marketed by Indi Pharma for the treatment of dry cough and associated upper respiratory symptoms such as sneezing, runny nose, and throat irritation. It is formulated as a fixed-dose combination containing chlorpheniramine maleate, a first-generation antihistamine, and dextromethorphan hydrobromide, a centrally acting cough suppressant. Chlorpheniramine maleate acts as an antagonist at the histamine H1 receptor to alleviate allergic symptoms, while dextromethorphan hydrobromide acts as an agonist at the sigma-1 receptor and an antagonist at the NMDA receptor to suppress the cough reflex in the brain.
- Brand names
- Expectus DExpectus D Cough SyrupExpectus D Syrup
- Other names
- chlorpheniramine maleate + dextromethorphan hydrobromidedextromethorphan + chlorpheniraminedextromethorphan hydrobromide + chlorpheniramine maleate
02
Targets
HRH1 (Histamine H1 Receptor)mAChR (Muscarinic acetylcholine receptors)SIGMAR1 (Sigma non-opioid intracellular receptor 1)KCNH2 (Voltage-gated potassium channel subfamily H member 2)NMDAR (Glutamate receptor ionotropic, NMDA)
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