Drug intelligence / Profile preview

chlorpheniramine + dextromethorphan (Juggat Pharma)

Development stage
Unknown
Lead developer
Juggat Pharma
Modality
Small Molecules
Administration
Oral
01

Overview

Panthor NF Syrup is an oral combination drug containing the first-generation antihistamine chlorpheniramine maleate and the centrally acting cough suppressant dextromethorphan hydrobromide. It is developed and marketed by Juggat Pharma for the temporary relief of dry cough, allergic cough, and associated symptoms such as sneezing, runny nose, and throat irritation. Chlorpheniramine maleate acts as a competitive antagonist at the histamine H1 receptor, reducing allergy-mediated symptoms, while dextromethorphan hydrobromide acts as a sigma-1 receptor agonist and NMDA receptor antagonist to suppress the cough reflex in the brainstem.

Brand names
Panthor NFPanthor NF Syrup
Other names
chlorpheniramine maleate + dextromethorphan hydrobromide
02

Targets

HRH1 (Histamine H1 Receptor)mAChR (Muscarinic acetylcholine receptors)NET (Norepinephrine Transporter)SIGMAR1 (Sigma non-opioid intracellular receptor 1)NMDAR (Glutamate receptor ionotropic, NMDA)

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