Drug intelligence / Profile preview

chlorpheniramine + paracetamol + phenylephrine (Med Manor Organics)

Development stage
Phase 3
Lead developer
Med Manor Organics
Modality
Small Molecules
Administration
Oral
01

Overview

Zincold is a fixed-dose combination medication developed by Med Manor Organics, primarily used to provide temporary relief from symptoms associated with the common cold, flu, allergic rhinitis, and seasonal allergies. It contains three active ingredients: paracetamol (an analgesic and antipyretic), phenylephrine hydrochloride (a nasal decongestant), and chlorpheniramine maleate (an antihistamine). Paracetamol works by inhibiting prostaglandin synthesis in the central nervous system to reduce fever and alleviate mild-to-moderate pain. Phenylephrine acts as a selective alpha-1 adrenergic receptor agonist, constricting blood vessels in the nasal passages to relieve congestion. Chlorpheniramine maleate is a first-generation histamine H1 receptor antagonist that blocks the action of endogenous histamine, thereby reducing allergic symptoms such as sneezing, runny nose, and watery eyes. Zincold is available in various pediatric and adult formulations, including tablets, syrups, and oral drops.

Brand names
ZincoldZincold DropsZincold Oral DropsZincold SyrupZincold Tablet
Other names
chlorpheniramine maleate + paracetamol + phenylephrine hydrochlorideparacetamol + phenylephrine + chlorpheniramine
02

Targets

ADRA1B (α1B)ADRA1D (α1D)HRH1 (Histamine H1 Receptor)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)ADRA1A (α1A)

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