Drug intelligence / Profile preview

chlorpheniramine maleate + paracetamol + phenylephrine hydrochloride

Development stage
Phase 3
Lead developer
Adwin Life Care
Modality
Small Molecules
Administration
Oral
01

Overview

ADCOLD DS is a combination pharmaceutical product developed by Adwin Life Care, primarily indicated for the symptomatic relief of the common cold and upper respiratory tract infections in pediatric patients. It is a multi-ingredient formulation typically containing an antipyretic and analgesic (paracetamol), a nasal decongestant (phenylephrine hydrochloride), and a first-generation antihistamine (chlorpheniramine maleate). Paracetamol works by inhibiting prostaglandin synthesis in the central nervous system to alleviate fever and pain. Phenylephrine acts as a selective alpha-1 adrenergic receptor agonist, causing vasoconstriction in the nasal passages to reduce congestion. Chlorpheniramine serves as a competitive H1 receptor antagonist, mitigating allergic symptoms such as sneezing, itching, and watery eyes. The "DS" designation typically refers to a "Double Strength" formulation, providing higher concentrations of active ingredients per dose compared to standard pediatric versions.

Brand names
ADCOLD DS
Other names
ADCOLD DS Suspension
02

Targets

ADRA1A (α1A)HRH1 (Histamine H1 Receptor)PTGS2 (Prostaglandin G/H synthase 2)KCNH2 (Voltage-gated potassium channel subfamily H member 2)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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