Drug intelligence / Profile preview

chlorpheniramine maleate + paracetamol + phenylephrine hydrochloride

Development stage
Unknown
Lead developer
Adwin Life Care
Modality
Small Molecules
Administration
Oral
01

Overview

ADCOLD DS is a combination pharmaceutical product developed by Adwin Life Care, primarily indicated for the symptomatic relief of the common cold and upper respiratory tract infections in pediatric patients. It is a multi-ingredient formulation typically containing an antipyretic and analgesic (paracetamol), a nasal decongestant (phenylephrine hydrochloride), and a first-generation antihistamine (chlorpheniramine maleate). Paracetamol works by inhibiting prostaglandin synthesis in the central nervous system to alleviate fever and pain. Phenylephrine acts as a selective alpha-1 adrenergic receptor agonist, causing vasoconstriction in the nasal passages to reduce congestion. Chlorpheniramine serves as a competitive H1 receptor antagonist, mitigating allergic symptoms such as sneezing, itching, and watery eyes. The "DS" designation typically refers to a "Double Strength" formulation, providing higher concentrations of active ingredients per dose compared to standard pediatric versions.

Brand names
ADCOLD DS
Other names
ADCOLD DS Suspension
02

Targets

COX-1 (Prostaglandin G/H synthase 1)HRH1 (Histamine H1 Receptor)PTGS2 (Prostaglandin G/H synthase 2)KCNH2 (Voltage-gated potassium channel subfamily H member 2)ADRA1A (α1A)

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