Drug intelligence / Profile preview

chlorproethazine

Development stage
Unknown
Modality
Small Molecules
Administration
Topical
01

Overview

Chlorproethazine is a drug of the phenothiazine group, structurally related to other phenothiazines such as chlorpromazine. It has been described as a muscle relaxant or tranquilizer and has been marketed in Europe, primarily as a topical cream for the treatment of muscle pain. Its primary use is for symptomatic relief of muscle pain rather than psychiatric indications. Chlorproethazine acts centrally and peripherally, consistent with other phenothiazines, but its detailed mechanism of action is not fully elucidated; it likely involves antagonism at dopamine receptors and possibly other neurotransmitter systems. The drug has also been associated with photoallergic contact dermatitis when used topically[1][3].

Brand names
Neuriplege
Other names
chlorproethazine
02

Targets

HTR2A (Serotonin receptor 5-HT2A)HRH1 (Histamine H1 Receptor)ADRA1A (α1A)DRD2 (Dopamine D2 Receptor)DRD3 (Dopamine receptor D3)ADRA1B (α1B)

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