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Drug intelligence / Profile preview
chlorproethazine
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Chlorproethazine is a drug of the phenothiazine group, structurally related to other phenothiazines such as chlorpromazine. It has been described as a muscle relaxant or tranquilizer and has been marketed in Europe, primarily as a topical cream for the treatment of muscle pain. Its primary use is for symptomatic relief of muscle pain rather than psychiatric indications. Chlorproethazine acts centrally and peripherally, consistent with other phenothiazines, but its detailed mechanism of action is not fully elucidated; it likely involves antagonism at dopamine receptors and possibly other neurotransmitter systems. The drug has also been associated with photoallergic contact dermatitis when used topically[1][3].
- Brand names
- Neuriplege
- Other names
- chlorproethazine
02
Targets
ADRA1A (α1A)ADRA1B (α1B)DRD2 (Dopamine D2 Receptor)DRD3 (Dopamine receptor D3)HRH1 (Histamine H1 Receptor)HTR2A (Serotonin receptor 5-HT2A)ADRA1 (Alpha-1 adrenergic receptor family)5-HT (Serotonin receptors)
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