chlorquinaldol

Chlorquinaldol is a halogenated hydroxyquinoline derivative with broad-spectrum antimicrobial and antiseptic properties. It is primarily used topically for the treatment of skin infections and as a vaginal tablet (often in combination with promestriene) for bacterial vaginosis and other gynecological infections. Chlorquinaldol exhibits bactericidal activity against both gram-positive and gram-negative bacteria—most notably staphylococci—and also demonstrates antifungal and antiparasitic effects. Its mechanism of action remains incompletely understood; while related 8-hydroxyquinolines act as metal ion chelators affecting enzyme cofactors, evidence suggests that chlorquinaldol’s primary antimicrobial effect does not rely on this property. Recent research indicates it may interact with methionine synthase reductase (MTRR), potentially contributing to its biological effects[1][2][3][4][5][6][7]. Chlorquinaldol is not commercially available in the United States but continues to be marketed in Europe under various trade names.

Brand names

SterosanCynotheraxGyno-SterosanSaprosanSiogenoSiosteranSlosteranSteroxin

Other names

5,7-dichloro-8-hydroxyquinoline