chlorquinaldol + promestriene

Chlorquinaldol + promestriene is a fixed-dose **combination drug** consisting of chlorquinaldol, a broad-spectrum topical antimicrobial agent, and promestriene, a synthetic estrogen derivative used for mucosal regeneration. Chlorquinaldol acts as a bacteriostatic and antifungal agent by altering the pH of pathogen cells, inhibiting metabolism, and leading to pathogen death; it does not induce phagocytosis by human epithelial cells, enhancing safety for mucosal applications[1][4][5]. Promestriene acts locally on reproductive tract mucosa to promote epithelial repair, restore the mucosal barrier, and avoid systemic estrogenic effects[3][4]. This combination is primarily formulated as vaginal tablets or soft capsules and is indicated for the treatment of bacterial vaginosis, chronic cervicitis (especially when complicated with HPV infection), cervical erosion, and abnormal vaginal discharge[1][2][3][4][5]. The combination has been shown to improve local and systemic immune markers (e.g., increase CD3+, CD4+, CD8+ T cells, reduce IL-1β, IL-6, IL-8, hs-CRP), improve epithelial healing, and increase HPV clearance[2][3][4]. The product is developed and manufactured in various forms (e.g., micro-emulsion capsules), with the aim to maximize mucosal absorption and local biological activity[5].

Brand names

Colposeptine

Other names

chlorquinaldol-promestriene vaginal tabletchlorquinaldol and promestriene vaginal tabletchlorquinaldol-promestriene vaginal soft capsulechlorquinaldol-promestriene micro-emulsion soft capsule