chlorsulfaquinoxaline

Chlorsulfaquinoxaline is a synthetic small molecule belonging to the sulfonamide class, structurally characterized as a chlorinated heterocyclic sulfanilamide. It has been investigated for its potential antineoplastic (anticancer) and immunosuppressive activities, particularly in clinical trials for lung cancer and colorectal cancer. Mechanistically, it acts by poisoning topoisomerase II alpha and beta enzymes, leading to double-stranded DNA breaks, accumulation of unrepaired DNA damage, and subsequent apoptosis of target cells. Additionally, it exhibits lymphotoxicity by inhibiting lymphocyte activation in a cell cycle-specific manner[1][6]. The compound is also known under the synonym "chloroquinoxaline sulfonamide" and has not been approved for human use but remains investigational.

Other names

chloroquinoxaline sulfonamide4-amino-N-(5-chloro-2-quinoxalinyl)benzenesulfonamide5-chloroquinoxaline-2-sulfanilamideCCRIS 689CCRIS689CCRIS-689