Drug intelligence / Profile preview

chlorthalidone

Development stage
Approved
Modality
Small Molecules
Administration
Oral
01

Overview

Chlorthalidone is a thiazide-like diuretic used to treat hypertension and edema caused by conditions such as heart failure, liver disease (cirrhosis), kidney disease, or steroid therapy. It works by increasing urine production, which helps reduce blood pressure and fluid buildup in the body. Chlorthalidone is often prescribed alone or in combination with other medications for managing high blood pressure and fluid retention.

Brand names
HygrotonThalitoneHemiclor
Other names
2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide2-chloro-5-(1-hydroxy-3-oxoisoindolin-1-yl)benzenesulfonamide(S)-2-chloro-5-(1-hydroxy-3-oxoisoindolinyl)benzenesulfonamide2-chloro-5-(3-hydroxyphthalimidinyl)benzenesulfonamideChlorothalidoneKLTG 33182G33182G-33182
02

Targets

SLC12A3 (Thiazide-sensitive sodium-chloride cotransporter)

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