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chlorzoxazone + diclofenac potassium + paracetamol
- Development stage
- Unknown
- Lead developer
- Thrift Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Tronac-MR is an oral fixed-dose combination tablet containing the skeletal muscle relaxant chlorzoxazone, the nonsteroidal anti-inflammatory drug (NSAID) diclofenac potassium, and the analgesic/antipyretic paracetamol (acetaminophen). Developed by Thrift Pharmaceuticals, it is indicated for the treatment of pain, inflammation, and muscle spasms associated with musculoskeletal disorders, such as sprains, strains, and muscle stiffness. Chlorzoxazone acts centrally on the spinal cord and subcortical areas of the brain to inhibit muscle spasms. Diclofenac potassium works by inhibiting cyclooxygenase (COX) enzymes, thereby reducing prostaglandin synthesis to alleviate pain and inflammation. Paracetamol provides additional analgesic and antipyretic effects, likely through central prostaglandin synthesis inhibition.
- Brand names
- Tronac-MR
- Other names
- chlorzoxazone + diclofenac + acetaminophenchlorzoxazone + diclofenac + paracetamolchlorzoxazone + diclofenac potassium + acetaminophenchlorzoxazone + diclofenac potassium + paracetamolchlorzoxazone, diclofenac and acetaminophenchlorzoxazone, diclofenac and paracetamolchlorzoxazone, diclofenac potassium and acetaminophenchlorzoxazone, diclofenac potassium and paracetamol
02
Targets
KCNMA1 (Calcium-activated potassium channel subfamily M alpha member 1)SPHK2 (Sphingosine kinase 2)KCNN4 (Intermediate conductance calcium-activated potassium channel protein 4)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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