chm-1

CHM-1 is a small molecule compound described chemically as 2'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone. It is a potent, selective antitumor agent shown to induce apoptosis (programmed cell death) in various human cancer cell lines, including hepatocellular carcinoma and ovarian cancer. CHM-1 acts as a vascular disrupting agent and exhibits antiangiogenic properties by inducing apoptosis in human endothelial cells and is noted for upregulating death receptor 5 (DR5) expression via p53 and p38 MAPK pathways, resulting in caspase-dependent apoptotic signaling. Its phosphate prodrug, CHM-1-P, also demonstrates significant antitumor activity in animal models[1][3][5].

Other names

2'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolonechm 1chm1chm-1