CHNQD-01522

CHNQD-01522 is a marine natural product-inspired small molecule microtubule inhibitor, specifically a 2-(3,4,5-trimethoxybenzoyl)quinazolin-4(3H)-one derivative. It was developed based on the structure of the marine alkaloid penipanoid C. The compound exerts its anti-tumor effects by binding to the colchicine binding site of tubulin, which inhibits microtubule polymerization, leads to G2/M phase cell cycle arrest, and induces apoptosis in cancer cells. CHNQD-01522 has shown significant potency against hepatocellular carcinoma (HCC) cell lines (Huh-7 and HepG2) and demonstrated robust anti-tumor efficacy in both subcutaneous and orthotopic xenograft mouse models. A key advantage of CHNQD-01522 is its ability to bypass P-glycoprotein (P-gp) mediated drug resistance, a common challenge for traditional microtubule-targeting agents like taxanes and vinca alkaloids.

Other names

2-(3,4,5-trimethoxybenzoyl)quinazolin-4(3H)-one derivative