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cholecalciferol + artificial tears
- Development stage
- Unknown
- Lead developer
- The University of Faisalabad
- Modality
- Small Molecules
- Administration
- Oral, Ophthalmic
01
Overview
Cholecalciferol (Vitamin D3) in combination with artificial tears is being investigated by the University of Faisalabad for the treatment of non-Sjögren dry eye syndrome in patients with vitamin D deficiency. Cholecalciferol is a fat-soluble vitamin that, upon conversion to its active form calcitriol, binds to the Vitamin D receptor (VDR). This interaction is thought to exert anti-inflammatory and anti-oxidative effects, potentially improving tear film stability and reducing ocular surface inflammation. In this clinical context, an oral dose of 6000 IU/day is administered alongside conventional topical artificial tears to evaluate synergistic improvements in ocular parameters such as tear breakup time (TBUT) and Ocular Surface Disease Index (OSDI) scores.
- Other names
- Vitamin D3cholecalciferolartificial tearsVitamin D3 Supplementation in Non-Sjogren Dry Eye
02
Targets
VDR (Vitamin D receptor)
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