cholesterol-conjugated let-7a

Cholesterol-conjugated let-7a (Chol-let-7a) is a synthetic microRNA mimic designed to restore the tumor-suppressive activity of the let-7a microRNA family, which is frequently downregulated in various cancers, including hepatocellular carcinoma (HCC). The molecule consists of a double-stranded RNA sequence identical to endogenous let-7a, with a cholesterol moiety covalently attached to facilitate systemic delivery and cellular uptake by interacting with lipoprotein receptors and cell membranes. This modification bypasses the need for traditional viral or lipid nanoparticle delivery systems. Once inside the cell, the let-7a mimic incorporates into the RNA-induced silencing complex (RISC) to post-transcriptionally repress oncogenic targets such as RAS, MYC, and HMGA2, thereby inhibiting tumor growth and progression. Preclinical studies have evaluated its antitumor efficacy and potential off-target effects, such as hepatic and renal toxicity.

Other names

cholesterol-conjugated let-7a mimicsChol-let-7a mimicsChol-let7a mimicsChol-let 7a mimics