Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
cholesterol-loaded liposomes
- Development stage
- Preclinical
- Lead developer
- Mario Negri Institute for Pharmacological Research
- Modality
- Small Molecules, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous, Intranasal
01
Overview
Cholesterol-loaded liposomes are lipid-based nanoparticles formulated to deliver exogenous cholesterol. In preclinical models of sepsis, these liposomes are used to restore depleted cholesterol levels in cell membranes, particularly in cardiomyocytes. Sepsis-induced hypocholesterolemia leads to a reduction in cardiomyocyte membrane cholesterol, which impairs beta-adrenergic receptor signaling and blunts the heart's responsiveness to catecholamines (such as dobutamine). By replenishing membrane cholesterol, cholesterol-loaded liposomes help restore adrenergic signaling and rescue myocardial function in sepsis-induced cardiomyopathy. Additionally, in the context of pneumococcal infections, these liposomes can act as decoy targets to bind and neutralize cholesterol-dependent cytolysins like pneumolysin.
- Other names
- cholesterol-enriched liposomesliposomal cholesterol
02
Targets
ADRB1 (β1)ADRB2 (β2)
Beyond the preview
Go deeper on cholesterol-loaded liposomes.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on cholesterol-loaded liposomes.