Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
choline
- Development stage
- Phase 4
- Lead developer
- Protara Therapeutics
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Choline is an essential nutrient that serves as a precursor for the neurotransmitter acetylcholine and is a key component in the synthesis of phospholipids such as phosphatidylcholine and sphingomyelin, which are vital for cell membrane integrity and function. Choline plays critical roles in nerve conduction throughout the central nervous system, liver function, fat metabolism (preventing excessive fat accumulation in the liver), gallbladder regulation, and methyl group donation via its metabolite betaine. It is also necessary for normal brain development and maintenance of cell structure. Choline deficiency can lead to fatty liver disease, high blood pressure, kidney dysfunction, stunted growth, and neurological disorders. Supplementation has been used to mitigate effects of Parkinsonism and tardive dyskinesia[1][5][6].
- Brand names
- Ilopan CholineVitaCholine
- Other names
- trimethylethanolaminevitamin B4
02
Targets
CHKA (Choline kinase)mAChR (Muscarinic acetylcholine receptors)α4β2 nAChR (Nicotinic acetylcholine receptor alpha4 beta2 subtype)CHRNA7 (α7 nicotinic receptor)AChR (Acetylcholine receptor)PCYT1B (Choline-phosphate cytidylyltransferase beta)SPT (Serine palmitoyltransferase)
Beyond the preview
Go deeper on choline.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on choline.