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choline geranate
- Development stage
- Phase 2
- Lead developer
- CAGE Bio
- Modality
- Drug Delivery Systems, Small Molecules
- Administration
- Topical
01
Overview
**Choline geranate** is a biocompatible ionic-liquid/deep-eutectic system composed of choline and geranic acid, developed by CAGE Bio for localized topical applications and as a dermal drug-delivery enhancer. Its direct antiseptic activity is attributed to geranate and geranic-acid components integrating into microbial membranes, causing membrane thinning, loss of membrane homeostasis, and disruption of biofilm extracellular material. It also interacts with stratum-corneum lipids to increase skin permeation of co-administered substances. A 1:2 choline:geranic-acid gel formulation, CGB-400, was evaluated clinically for rosacea, including a completed Phase 2 trial of 40% topical gel. ([journals.plos.org](https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0222211))
- Brand names
- CGB400CGB-400CGB 400
- Other names
- CAGEcholine and geranic acid
02
Targets
Stratum corneum lipid matrix
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