Drug intelligence / Profile preview

Chondrolife

Development stage
Preclinical
Lead developer
National University of Pharmacy
Modality
Small Molecules
Administration
Topical
01

Overview

Chondrolife is a topical combination cream-gel containing glucosamine hydrochloride, chondroitin sulfate, camphor, and menthol, developed for the treatment of osteoarthritis. It is designed to provide both chondroprotective and analgesic effects by modulating inflammation, regulating chondrocyte metabolism, and stimulating cartilage synthesis. Preclinical studies in rat models of carrageenan-induced acute gonarthritis have demonstrated that Chondrolife possesses significant antinociceptive activity, showing superior efficacy compared to chondroitin-only topicals and comparable early-phase efficacy to diclofenac-based gels. The formulation leverages the synergistic effects of cartilage matrix precursors and sensory modulators to address the pain and structural degradation associated with joint disease.

Brand names
Chondrolife
Other names
Хондролайф
02

Targets

MMP12 (Macrophage Metalloelastase)TRPV1 (Transient receptor potential cation channel subfamily V member 1)TRPM8 (Transient receptor potential cation channel subfamily M member 8)

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