CHOP siRNA

CHOP siRNA is a small interfering RNA (siRNA) designed to target and silence the expression of CCAAT/enhancer-binding protein homologous protein (CHOP), also known as DNA damage-inducible transcript 3 (DDIT3). CHOP is a transcription factor that is strongly induced under conditions of severe or prolonged endoplasmic reticulum (ER) stress and acts as a key mediator of ER stress-induced apoptosis. In preclinical research, CHOP siRNA is utilized to investigate the role of CHOP-mediated apoptotic pathways in various pathological conditions, including type 2 diabetes, insulin resistance, ischemic stroke, acute kidney injury, and myocardial ischemia. Silencing CHOP with siRNA has been shown to reduce apoptosis, attenuate inflammatory signaling, and improve cell survival and metabolic homeostasis in various in vitro and in vivo animal models.

Other names

CHOP small interfering RNADDIT3 siRNADDIT-3 siRNADDIT 3 siRNAGADD153 siRNAGADD-153 siRNAGADD 153 siRNAsiCHOP