Drug intelligence / Profile preview

choriogonadotropin alfa + biotin

Development stage
Unknown
Lead developer
Merck KGaA
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Recombinant Proteins and Enzymes
Administration
Subcutaneous (choriogonadotropin Alfa), Intramuscular (choriogonadotropin Alfa, Some Formulations), Oral (biotin), Intravenous (biotin, Rarely)
01

Overview

**Choriogonadotropin alfa + biotin** is a combination product that would contain both choriogonadotropin alfa, a recombinant form of human chorionic gonadotropin hormone used primarily to induce ovulation and treat female infertility, and biotin, a water-soluble B vitamin (vitamin B7) known as a coenzyme for carboxylase enzymes involved in fatty acid synthesis, amino acid metabolism, and gluconeogenesis. Choriogonadotropin alfa works by binding to and activating the luteinizing hormone/chorionic gonadotropin receptor, mimicking the action of endogenous luteinizing hormone to induce ovulation in females. Biotin serves as an essential cofactor for metabolic enzymes and is clinically relevant for treating or preventing biotin deficiency, but is not a standard treatment for infertility or reproductive indications. There is no evidence of a marketed or clinically developed combination of these two agents; this entry describes their known pharmacology as monocomponents[1][2][3][6].

02

Targets

LHCGR (Luteinizing hormone/choriogonadotropin receptor)

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