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Drug intelligence / Profile preview
CHP-NY-ESO-1
- Development stage
- Unknown
- Lead developer
- ImmunoFrontier
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes, Nanoparticles → Drug Delivery Systems
- Administration
- Subcutaneous
01
Overview
CHP-NY-ESO-1 is a cancer vaccine developed by the Ludwig Institute for Cancer Research in collaboration with ImmunoFrontier. It consists of the recombinant protein NY-ESO-1, a highly immunogenic cancer/testis antigen, complexed with cholesterol-bearing hydrophobized pullulan (CHP). CHP serves as a nanoparticle-forming delivery vehicle that facilitates the uptake of the antigen by antigen-presenting cells, subsequently activating both CD4+ and CD8+ T-cell immune responses. The vaccine is primarily investigated for the treatment of advanced solid tumors, including melanoma and esophageal cancer, that express the NY-ESO-1 antigen.
- Other names
- NY-ESO-1 protein vaccineNY-ESO1 protein vaccineNY-ESO 1 protein vaccineCHP-NY-ESO-1 vaccineCHP-NY-ESO1 vaccineCHP-NY-ESO 1 vaccineNY-ESO-1 recombinant protein + CHP
02
Targets
NY-ESO-1 (New york esophageal squamous cell carcinoma 1)
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