chromium picolinate + biotin

Chromium picolinate + biotin is an oral fixed-dose nutritional supplement combination developed and marketed by Nutrition 21 as **Diachrome**. The studied formulation supplied 600 mcg elemental chromium as chromium picolinate plus 2 mg biotin once daily and was evaluated as an adjunct to stable oral antidiabetic therapy in people with poorly controlled type 2 diabetes mellitus. Chromium is proposed to support insulin signaling and glucose transporter trafficking, while biotin is a cofactor for carboxylase enzymes and may influence glucose-metabolism gene regulation. Randomized studies reported improvements in glycemic and selected lipid measures, but the combination is a dietary supplement rather than a conventional approved pharmaceutical antidiabetic medicine. ([europepmc.org](https://europepmc.org/article/MED/17506119))

Brand names

Diachrome

Other names

CPBchromium picolinate plus biotinchromium picolinate with biotinchromium picolinate/biotin