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Chrysanthemum flower oil is an essential oil obtained through steam distillation or solvent extraction from the flowering heads of plants in the *Chrysanthemum* genus, most notably *Chrysanthemum morifolium* and *Chrysanthemum indicum*. In Traditional Chinese Medicine (TCM), it is valued for its cooling properties and is frequently used to treat symptoms associated with 'wind-heat,' such as headaches, dizziness, and ocular inflammation. The oil is a complex mixture of bioactive volatile compounds, including monoterpenes like camphor, borneol, and 1,8-cineole, as well as various sesquiterpenes and flavonoids. Pharmacologically, it demonstrates significant anti-inflammatory, antioxidant, and antimicrobial activities. Its mechanism of action involves the inhibition of pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), primarily through the suppression of the NF-κB signaling pathway. It is also utilized in aromatherapy for its purported sedative and anxiolytic effects.
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