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Chuangling Ye
- Development stage
- Phase 1
- Lead developer
- Jiangsu Provincial Hospital of Traditional Chinese Medicine
- Administration
- Topical
01
Overview
Chuangling Ye (CLY) is a traditional Chinese herbal medicine formula primarily utilized for the treatment of chronic inflammatory wounds and ulcers, most notably diabetic foot ulcers (DFU) and plasma cell mastitis abscesses. As a multi-component herbal preparation, it contains approximately 61 active compounds that interact with a broad network of molecular targets. Network pharmacology studies have identified key biological targets including EGFR, TP53, CCND1, IL-1B, and PTGS2, suggesting a mechanism of action that involves modulating inflammatory responses and promoting tissue repair. The formula is typically administered topically as a solution for rinsing or via saturated gauze drainage to improve local inflammatory conditions in abscesses, sinuses, or fistulas.
- Other names
- Chuang-Ling-Ye疮灵液
02
Targets
CCND1 (Cyclin D1)CREBBP (CREB-binding protein)EGFR (Epidermal growth factor receptor)IL1B (Interleukin-1 beta)PR (Progesterone receptor)TP53 (Cellular Tumor Antigen p53 R175H)
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