Chuanxiong Qingnao

Chuanxiong Qingnao (川芎清脑颗粒, CQG) is a proprietary Chinese patent medicine formulation used primarily in the prevention and treatment of migraine and headache disorders. It is composed mainly of botanical medicines, with the core ingredient being *Ligusticum chuanxiong* (Chuanxiong), combined with other traditional Chinese herbs, though the exact composition may vary by manufacturer. Chuanxiong Qingnao is reported, in randomized controlled trials, to reduce migraine frequency, severity, headache days, disability, fatigue, and depressive symptoms, with a favorable safety profile in clinical use[4][3][8][9]. The mechanism of action, elucidated through transcriptomics and metabolomics research, includes modulation of neuroinflammation and key signaling pathways: inhibition of the PI3K/Akt pathway, reduction of pro-inflammatory cytokines (including interleukin-17A, interleukin-13, and CC chemokine receptor type 3), and regulation of glycerophospholipid metabolism[1]. These multi-target effects are thought to underlie its efficacy in migraine and possibly other neurological or vascular conditions.

Brand names

Chuanxiong QingnaoChuanxiong Qingnao GranuleChuanxiong Qingnao Granules川芎清脑颗粒

Other names

CQGChuanxiong Qingnao Granule