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cichorium intybus extract
- Development stage
- Phase 3
- Lead developer
- Phytomedics
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
cichorium intybus extract (commonly known as chicory extract) is a botanical extract derived from the roots, seeds, or aerial parts of the *Cichorium intybus* plant. It is rich in bioactive compounds, including inulin (a prebiotic fiber), sesquiterpene lactones (such as lactucin and lactucopicrin), and polyphenols (such as chicoric acid and chlorogenic acid). The extract has been investigated for its anti-inflammatory, antioxidant, hepatoprotective, and metabolic regulatory properties. In clinical and preclinical studies, it has been evaluated for the management of osteoarthritis, non-alcoholic fatty liver disease (NAFLD), and type 2 diabetes mellitus. Phytomedics, Inc. sponsored a Phase 1 clinical trial evaluating a proprietary bioactive extract of chicory root for the treatment of osteoarthritis of the hip or knee.
- Other names
- Cichorium intybus L. extractCichorium intybus root extractCichorium intybus seed extractchicory extractchicory root extract
02
Targets
IL1B (Interleukin-1 beta)IL-6 (Interleukin 6)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)TNFA (Tumor necrosis factor alpha (soluble))
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