Drug intelligence / Profile preview

ciclesonide + levocetirizine + montelukast

Development stage
Preclinical
Lead developer
Takeda
Modality
Small Molecules
Administration
Oral, Inhalation, Intranasal
01

Overview

A combination therapy consisting of ciclesonide (a corticosteroid), levocetirizine (an antihistamine), and montelukast (a leukotriene receptor antagonist). This combination targets multiple pathways involved in allergic and inflammatory responses. Ciclesonide reduces inflammation in the airways, levocetirizine blocks histamine receptors to reduce allergy symptoms, and montelukast inhibits leukotriene receptors which play a role in both asthma and allergic rhinitis.

02

Targets

CYSLTR1 (Cysteinyl-leukotriene type 1 receptor)GR (Glucocorticoid receptor)HRH1 (Histamine H1 Receptor)

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