cicloprofen

Cicloprofen is a non-steroidal anti-inflammatory drug (NSAID) belonging to the propionic acid derivative class, chemically identified as a fluorene derivative. It functions primarily as an inhibitor of the cyclooxygenase (COX) enzymes, thereby blocking the synthesis of prostaglandins that mediate pain, inflammation, and fever. Historically developed by Squibb (as SQ 20824) for the treatment of inflammatory conditions such as rheumatoid arthritis and osteoarthritis, its clinical use has been largely superseded by other NSAIDs. In recent clinical research contexts, particularly in China, it has been investigated as an adjunct analgesic in multimodal anesthesia regimens. For instance, it has been evaluated alongside agents like oliceridine, alfentanil, and dexmedetomidine to provide perioperative analgesia and potentially mitigate adverse events such as respiratory depression and hemodynamic instability during procedural sedation for gastrointestinal endoscopy.

Other names

cycloprofen2-(9H-fluoren-2-yl)propanoic acid2-(2-fluorenyl)propionic acid