CID2858522

CID2858522 is a small molecule research compound that functions as a selective inhibitor of protein kinase C (PKC)-mediated NF-κB activation. Identified through high-throughput screening as part of the Molecular Libraries Probe Production Centers Network (MLPCN), it specifically blocks the signaling pathway downstream of PKC that leads to the activation of the transcription factor NF-κB. In laboratory settings, CID2858522 has demonstrated the ability to inhibit the viability of cancer cells, particularly esophageal squamous cell carcinoma (ESCC), in a dose-dependent manner. It is primarily utilized as a pharmacological tool or chemical probe to investigate the role of PKC and NF-κB signaling in inflammatory and oncogenic processes and is commercially available from research chemical suppliers such as Sigma-Aldrich.

Other names

1-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dimethyl-1H-benzimidazol-1-yl]-ethanone758679-97-9