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CIGB-210
- Development stage
- Unknown
- Lead developer
- Center for Genetic Engineering and Biotechnology
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
CIGB-210 is an experimental small molecule antiviral drug candidate developed by the Cuban Center for Genetic Engineering and Biotechnology (CIGB). It functions as a calmodulin antagonist, targeting the calcium-binding protein calmodulin, which is a critical host factor utilized by various viruses for replication, assembly, and budding. Originally investigated for the treatment of HIV-1 infection, CIGB-210 was repositioned during the COVID-19 pandemic to evaluate its potential in inhibiting SARS-CoV-2 replication. The drug aims to disrupt the viral life cycle by interfering with the interaction between calmodulin and viral proteins. Clinical trials in Cuba have explored its safety and antiviral effect in both HIV-1 and COVID-19 patients, typically utilizing an oral tablet formulation.
- Other names
- CIGB-210CIGB210CIGB 210
02
Targets
CaM (Calmodulin)
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