cilazaprilat

Cilazaprilat is the active metabolite of cilazapril, a long-acting angiotensin-converting enzyme (ACE) inhibitor. It works by inhibiting ACE, thereby blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This leads to decreased vasoconstriction and reduced sodium and water reabsorption via aldosterone, resulting in lower blood pressure and improved symptoms in heart failure. Cilazaprilat is used primarily for the treatment of hypertension and congestive heart failure[1][4][5][6]. The drug also helps protect kidney function in patients with diabetic nephropathy[7]. Cilazapril is a prodrug that is hydrolyzed after absorption to form cilazaprilat, which exerts the pharmacological effects[5].

Other names

cilazaprilat